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Plasma Sci. Technol. ›› 2018, Vol. 20 ›› Issue (4): 044005.doi: 10.1088/2058-6272/aa9b79

• Plasma Biomedicine • Previous Articles     Next Articles

Pulsed cold plasma-induced blood coagulation and its pilot application in stanching bleeding during rat hepatectomy

Keping YAN (闫克平)1, Qikang JIN (金杞糠)1, Chao ZHENG (郑超)2 , Guanlei DENG (邓官垒)1, Shengyong YIN (殷胜勇)3 and Zhen LIU (刘振)1   


  1. 1 Institute of Industrial Ecology and Environment, Zhejiang University, Hangzhou 310007, People’s Republic of China 2 Zhejiang Center for Medical Device Adverse Events Monitoring and Safety Research, Hangzhou 310009, People’s Republic of China 3 Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China
  • Received:2017-10-09 Published:2017-11-14
  • Supported by:

    This work is supported by National Natural Science Foundation of China (51377145) and the Science and Technology Program of Zhejiang Province (2015F10011 and 2014C33022), China.


This paper presents plasma-induced blood coagulation and its pilot application in rat hepatectomy by using a home-made pulsed cold plasma jet. Experiments were conducted on blood coagulation in vitro, the influence of plasma on tissue in vivo, and the pilot application of rat hepatectomy. Experimental results show that the cold plasma can lead to rapid blood coagulation. Compared with the control sample, the plasma-induced agglomerated layer of blood is thicker and denser, and is mostly composed of broken platelets. When the surface of the liver was treated by plasma, the influence of the plasma can penetrate into the liver to a depth of about 500 μm. During the rat hepatectomy, cold plasma was proved to be effective for stanching bleeding on incision. No obvious bleeding was found in the abdominal cavities of all six rats 48 h after the hepatectomy. This implies that cold plasma can be an effective modality to control bleeding during surgical operation.

Key words: cold plasma jet, blood coagulation, stanching bleeding, hepatectomy, plasma medicine