Evaluations of dielectric property and drug release profile of 5-FU patches based on plasma charged electrets

Wang YUAN (苑旺); Hejuan LIANG (梁合鹃); Ping HUANG (黄平); Xiaoqiang AN (安晓强); Jian JIANG (江键); Lili CUI (崔黎丽)

doi:10.1088/2058-6272/aaa598

Plasma Science and Technology > 2018 > 20(5): 54015-054015. > DOI: 10.1088/2058-6272/aaa598

Wang YUAN (苑旺), Hejuan LIANG (梁合鹃), Ping HUANG (黄平), Xiaoqiang AN (安晓强), Jian JIANG (江键), Lili CUI (崔黎丽). Evaluations of dielectric property and drug release profile of 5-FU patches based on plasma charged electrets[J]. Plasma Science and Technology, 2018, 20(5): 54015-054015. DOI: 10.1088/2058-6272/aaa598

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Evaluations of dielectric property and drug release profile of 5-FU patches based on plasma charged electrets

1 Department of Physics and Mathematics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, People’s Republic of China 2 Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, People’s Republic of China

Funds: The authors thank National Natural Science Foundation of China (Grant No. 51477175) for financial support.

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Received Date: October 29, 2017

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Abstract

Abstract

In the present study, the electret 5-fluorouracil patch was developed, the effective surface potential, piezoelectric coefficient d₃₃, open-circuit thermally stimulated discharge (TSD) current spectra and shear adhesion of the patch were measured. The drug release profile of the patch was determined by using high performance liquid chromatography method. A stable potential difference which was positively dependent on the surface potential of the electret was generated on two sides of the patch. The measurements of d₃₃ coefficient, TSD current spectra and adhesion performance showed that the electrostatic field of the electret could cause polarization and cohesive strength decreasing of the matrix molecules, change the distribution and interaction of the drug molecules in patch, therefore to increase the release of drug from the transdermal patch.
- electret,
- hypertrophic scar,
- thermally stimulated discharge current,
- 5-fluorouracil,
- patch,
- piezoelectric coefficient

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References (14)

References

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